Formulation and evaluation of fast dissolving tablets of captopril

Oral administration is the most popular route for systemic effects due to its ease of ingestion, pain, avoidance, versatility and importantly, patient compliance. The development enhanced oral protein delivery technology by mouth dissolving Tablets which may release these drugs in are very promising high molecular weight peptide. Good feel property MDDS helps change basic view medication as “bitter pill”, particularly pediatric patients. To prepare tablet using SSG & CCM Antihypertensive model drug. Captopril a potent, competitive inhibitor angiotensin-converting enzyme it key component renin-angiotensin-aldosterone system. ƛmax was determined scanning 10µg / ml solution drug UV-Spectrophotometer found be 271nm. linear correlation 0.9995.The Fast tablets captopril were prepared direct compression method. can successfully formulated various super disintegrate different concentrations formulation containing 10% crospovidone disintegrated outstanding than other formulations terms disintegration time rate dissolution.